The an excitation of a skeletal muscle fiber

The
first physiological event that’s surrounds the activation of neuromuscular
junction is when there is an excitation of a skeletal muscle fiber which
results in the release of the neurotransmitter ACh. The action potent ion, Calcium,
must first enter the synaptic knob when the nerve signals triggers the opening
of the voltage gated Ca2+ (McKinley, 2015). This will allow the calcium to move
from the interstitial fluid and down the concentration gradient into the
synaptic knob. Once the calcium binds with the synaptic vesicles, it will cause
the vesicles to merge with the plasma membrane (McKinley, 2015). As a result of
the the influx of calcium into the neuron, the neuromuscular ACh is released
into the synaptic cleft.  Acetylcholine
is released from approximately 300 vesicles per nerve signal with each vesicle
releasing thousands of molecules of ACh (McKinley, 2015). The acetylcholine is
then diffused across the synaptic cleft filled with calcium to start binding
with the ACh receptors located in the motor end plate and the motor neuron. This
caused the skeletal muscle fibers to get excited and contract. In other words,
the action potential is being triggered.