Nanotechnology deals with the nanoparticles having a size of1–100 nm in one dimension. Nowadays, nanoparticles havebeen used commercially for a wide variety of coating areasincluding electronics, energy contact actions, and medicines.AgNPs play a major part in the commercial applications ofthese nanoparticles in the field of pharmaceutical and othermedical sciences (Fig. 1). Biosynthesized AgNPs are moreacceptable for medical applications due to superior biocompatibilitythan chemically synthesized ones. The use of greenchemistry involving plant extract and microbes is environmentalfriendly, non-toxic, and cheap 1. The recent strategyto improve the efficacy of drugs is to combine them with metalnanoparticles for the control of microbial infections 2.Interaction of AgNPs with heavy metal in the biological removalprocess remains poorly understood. Yanan et al. 3showed that the biological removal electrical capacity ofheavy metals increased with the concentration of AgNPs, suggestingthat an appropriate concentration ofAgNPs has a stimulatingeffect on the removal of heavy metals byPhanerochaete chrysosporium. AgNPs possess unique attributeswhich are breakthrough myriad applications such asantimicrobial, anticancer, larvicidal, catalytic, and wound healing activities 4. During the last 5 years, many effortswere put into developing new greener and cheaper methodsfor the synthesis of nanoparticles 5. The biosynthesis ofnanoparticles has been proposed as a cost-effective and environmentalfriendly alternative to chemical and physicalmethods 6. A number of microorganisms such as bacteria,fungus, yeasts, and plants either intra- or extracellular whichare of higher crop yields and lower expenses have been discoveredto be capable of synthesizing nanoparticles 7. Thepurpose of our investigation is to open new perspectives andthe future applications of nanomaterial biosynthesis as beingpotential antimicrobial agents.