Cellulitis and subcutaneous tissues.1 Cellulitis can cause mild

Cellulitis
is characterised by an acute, diffuse, spreading, oedematous non suppurative
inflammation of the dermis and subcutaneous tissues.1 Cellulitis can
cause mild discomfort to severe complications like sepsis, local gangrene,
necrotising fasciitis, septicaemia which can lead to death.2
Condition of necrotising fasciitis is very dangerous which has 39% of mortality
rate.3

Cellulitis is usually caused by ?-hemolytic
streptococci (BHS) that are susceptible to penicillin and other narrow-spectrum
antibiotics4. However, there are significant treatment challenges,
including overuse of broad-spectrum and intravenous antibiotics5,6,
difficulties regarding when to initiate rescue therapy and when to stop
treatment7, and frequent recurrences8. Toxin effects and profound local
inflammation, not necessarily corresponding to bacterial burden or antibiotic
needs, may contribute to these problems7,9. Also, host factors
affecting the dynamics of treatment response may adversely impact antibiotic
choices and other resource use.

Clavulanic
acid, a naturally occurring betalactamase inhibitor, has been shown to prevent
the enzymatic degradation of beta-lactam antibiotics by a number of bacterial
species. Combinations of clavulanic acid and amoxicillin (ACA) show greater
activity in vitro against these bacteria than does amoxicillin alone 10,11,12.
Clinical trials in adults have shown that ACA is effective against SSI, respiratory
and urinary tract infections caused by ampicillin-susceptible and ampicillin resistant
organisms 13, 14,15, 16, 17.

?-Lactamase inhibitors are themselves ?-lactam
antibiotics, usually with minimal or no antibacterial activity. When combined
with certain ?-lactam antibiotics, they augment the potency of these against
?-lactamase-producing bacteria. Sulbactam is a commercially available
?-lactamase inhibitor. Ceftriaxone
is a type of antibiotic called a cephalosporin. These antibiotics are related
to penicillin. Ceftriaxone is used to treat infections with bacteria.Ceftriaxone
is used in combination with sulbactam for the treatment of soft tissue
infections.The potency of antibiotic drugs increases manifold when combined
with ?-Lactamase inhibitors.

 

This study will compare the efficacy of
amoxicillin and clavulanic acid versus ceftriaxone and sulbactum in patients
suffering from cellulitis.